Brain Vulnerability to Repeated Blast Overpressure and Polytrauma

نویسنده

  • Joseph B. Long
چکیده

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Award Number: W81XWH-08-2-0018 TITLE: Brain Vulnerability to Repeated Blast Overpressure and Polytrauma PRINCIPAL INVESTIGATOR:

TITLE: Brain Vulnerability to Repeated Blast Overpressure and Polytrauma PRINCIPAL INVESTIGATOR: Joseph B. Long, Ph.D. CONTRACTING ORGANIZATION: The Geneva Foundation Tacoma, WA 98402 REPORT DATE: November 2013 TYPE OF REPORT: Final PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for public release; distribution un...

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Award Number: W81XWH-08-2-0018 TITLE: "Brain Vulnerability to Repeated Blast Overpressure and Polytrauma” PRINCIPAL INVESTIGATOR: Joseph B. Long, PhD CONTRACTING ORGANIZATION: The Geneva Foundation

Age-dependent variations in the pathophysiology of blast-induced traumatic brain injury (bTBI) may influence efficacy of therapies for mitigation of damage. Since War fighters who sustain bTBI are typically exposed to a combination of blast overpressure (BOP) and a biomechanical perturbation related to acceleration and/or impact, BOP and weight drop injury were combined into a dual insult model...

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Rapid Release of Tissue Enzymes into Blood after Blast Exposure: Potential Use as Biological Dosimeters

Explosive blast results in multiple organ injury and polytrauma, the intensity of which varies with the nature of the exposure, orientation, environment and individual resilience. Blast overpressure alone may not precisely indicate the level of body or brain injury after blast exposure. Assessment of the extent of body injury after blast exposure is important, since polytrauma and systemic fact...

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Simulated blast overpressure induces specific astrocyte injury in an ex vivo brain slice model

Exposure to explosive blasts can produce functional debilitation in the absence of brain pathology detectable at the scale of current diagnostic imaging. Transient (ms) overpressure components of the primary blast wave are considered to be potentially damaging to the brain. Astrocytes participate in neuronal metabolic maintenance, blood-brain barrier, regulation of homeostatic environment, and ...

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Significant head accelerations can influence immediate neurological impairments in a murine model of blast-induced traumatic brain injury.

Although blast-induced traumatic brain injury (bTBI) is well recognized for its significance in the military population, the unique mechanisms of primary bTBI remain undefined. Animate models of primary bTBI are critical for determining these potentially unique mechanisms, but the biomechanical characteristics of many bTBI models are poorly understood. In this study, we examine some common shoc...

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تاریخ انتشار 2012